Chloe
Evidence Intelligence and Knowledge Creation
Chloe leads the agents responsible for discovering, extracting, structuring, and synthesizing evidence.
Kesis & Sisters is building Nyx
Building an agent-native organization for clinical knowledge.
Kesis & Sisters is building Nyx, where specialized agent teams create, interpret, govern, and maintain computable clinical knowledge. Applications are built from that knowledge.
Company Kesis & Sisters
Flagship in active development Nyx
ChloeKesisAtro
Governed, computable clinical knowledge
expressed through applications
The problem
Evidence does not arrive as usable clinical knowledge.
Medical evidence is fragmented, context-dependent, and always changing. The hard work is turning it into structured knowledge that can be reviewed, maintained, and used safely across software applications.
- 01 Fragmented
Relevant evidence sits across publications, guidelines, standards, and data sources.
- 02 Context-dependent
A result gains meaning only when population, setting, applicability, and uncertainty are understood.
- 03 Difficult to maintain
Applications need traceable, versioned knowledge that can change without losing its history.
Meet Nyx
An organization built around the work clinical knowledge requires.
Nyx is an agent-native clinical knowledge organization. It is being developed around defined functions, responsibilities, handoffs, review, and lifecycle management.
In active development Nyx Agent-native clinical knowledge organization
ChloeEvidence intelligence and knowledge creation
KesisClinical interpretation and composition
AtroKnowledge governance and publication
From evidence to knowledge
Applications begin with a shared knowledge foundation.
Nyx is being built to turn medical evidence into governed, computable clinical knowledge. Applications express that knowledge for different users and decisions.
01 Medical evidence Published sources and standards
02 Nyx Specialized functions and governed handoffs
03 Governed, computable clinical knowledge Traceable, reviewable, versioned
04 Applications Different expressions for different users
The Sisters
Functional leadership inside Nyx.
Chloe, Kesis, and Atro define three connected responsibilities in the organization being built. They are agent leaders, not human executives or decorative personas.
Kesis
Clinical Interpretation and Composition
Kesis leads the agents responsible for contextualizing evidence, assessing applicability, modelling outcomes, and composing clinical knowledge.
Atro
Knowledge Governance and Publication
Atro leads the agents responsible for validation, review orchestration, publication control, versioning, supersession, and retirement.
What we are testing
Three applications. One developing knowledge foundation.
Kesis applications are being used to test how governed clinical knowledge developed through Nyx can support different users, clinical contexts, and decisions.
Kesis Clinical — Kidney Cancer
A clinician-facing application currently being used to test how governed clinical knowledge developed through Nyx can support complex kidney cancer decisions.
Kesis Clinical — GIST
A clinician-facing application in clinical testing for gastrointestinal stromal tumour decision support.
Kesis Companion — Breast Cancer
A patient-facing application in testing, designed to express governed clinical knowledge in a form appropriate for patients.
Testing status does not imply commercial availability, regulatory validation, routine clinical deployment, or demonstrated clinical benefit.
See the applications
The company behind Nyx
Built from clinical practice, evidence, policy, and engineering.
Kesis & Sisters is the company building Nyx. Founder Dr. Henry Conter is a practising medical oncologist whose work spans oncology, health technology assessment, quantitative analysis, pharmaceutical strategy, and software.
That combination shapes the company’s central question: how can complex evidence become knowledge that remains clear enough to inspect, govern, and use in real decisions?
About Kesis & SistersInsights
Clinical decisions, evidence, and where technology belongs.
Writing from the perspective of a working oncologist building systems for the decisions that remain difficult.
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Read insightCollaborate
Build the next layer with us.
We are interested in clinical testing, research, application development, and strategic collaboration around agent-native clinical knowledge systems.